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22 East 65th Street, 5th Floor


$15,000 monthly

($72 psf)


2,500 sf

~16 employees

Lease Term


Direct Lease

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About the Building

Building Amenities

Walk Score: 99


22 East 65th Street, New York, NY 10065



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Upper East Side

To many people, the Upper East Side of Manhattan evokes images of affluence and luxury. It is indeed one of NYC’s most expensive neighborhoods, and is known for upscale apartments, prep schools, and designer boutiques—though one can find affordable living spaces here as well.

A Great Neighborhood for High-end New York Offices

Though New York’s Upper East Side—sometimes nicknamed UES—is mostly residential, it has many unique characteristics that make it ideal for some businesses to lease. In particular, high-end retailers and galleries may find the perfect location in the Upper East Side, which has a notoriously upscale population and is also close to major tourist locations like Central Park and transit hub Grand Central Terminal.

Companies that lease office space in the Upper East Side section of New York City include Annie and Company Needlepoint, French Bull, dineen architecture + design, as well as the New York offices of National Geographic.

Types of Businesses That May Seek Office for Rent on the Upper East Side

With the United Nations located just below the Upper East Side in the East 40s, diplomatic missions and consulates often occupy the former mansions of the UES neighborhood, so companies with international connections might find it suitable to have Upper East Side office space.

Medical sector businesses may also want to lease offices in this New York NY neighborhood, with Memorial Sloan Kettering Cancer Center and Weill Cornell Hospital among the distinguished medical institutions in the area. Campuses of medical schools such as Hunter College, Rockefeller University, and Fordham University are also on the Upper East Side, attracting students and recent graduates who form a skilled talent pool.

Given the average size of the units available, many of the office buildings on the Upper East Side are particularly ideal for small or mid-sized businesses.

Amenities for Companies Renting Office Space on the Upper East Side NY

The Upper East Side offers excellent restaurants, ideal for business lunches. It is also home to an impressive collection of museums and galleries such as the Guggenheim Museum and the Metropolitan Museum of Art, located on the “Museum Mile” section of Fifth Avenue.

Need to get out of the office and take a stroll? Central Park is a conveniently located oasis, perfect for relaxing, exercising, or enjoying lunch outside.

Upper East Side Office Space Rentals | Lease Data & Trends

Newer commercial office spaces for lease on the Upper East Side tend to be located on the east side of Third Avenue, while historic Class A and Class B buildings constructed in the 1920s are more common along Park Avenue and Fifth and Madison Avenues. Office suites and entire floors compose a significant portion of the available office space in the Upper East Side.

Transportation for Upper East Side Office Workers

Commuting to and from the Upper East Side has become much more convenient following the completion of the Second Avenue subway in early 2017. The Q train now runs from 72nd Street up to 96th Street and diverts congestion from the 4, 5, and 6 lines. Suburban commuters can connect to the Lexington Avenue line at Grand Central Station.

Bounded by 59th Street, Central Park, 96th Street, and the East River, the Upper East Side is composed of three smaller neighborhoods: Lenox Hill, Carnegie Hill, and Yorkville. Nearby Manhattan neighborhoods include MidtownPlaza District, Park Avenue, the Upper West Side, and Harlem.

Top Commercial Properties For Lease In Upper East Side New York

To learn more about open office space in the Upper East Side during your office rental search, talk to one of our experienced brokers. You can also check out one of these Squarefoot-recommended properties:

645 Madison Avenue: 645 Madison Avenue, an office building sometimes called the Pan Ocean Building on the Upper East Side, was built in 1971 and stretches 22 stories (274 feet) high. The Class A office building offers 140,232 square feet of rentable space, which is most suitable for small or mid-sized organizations. Roc Capital Management, Nahla Capital Management, and Honeycomb Asset Management all lease offices here.

14 East 60th Street: 14 East 60th Street is a Class B office building 12 stories high on the Upper East Side. Because it does not offer large blocks of contiguous space, this building would be most ideal for small or mid-sized companies. Erika Bloom Pilates, Avra, and The Green Fund are all current tenants.

654 Madison Avenue: Built in 1927, 654 Madison Avenue is a boutique office building with 143,524 square feet of rentable space spread throughout 23 stories on the Upper East Side. The building tends to attract financial service companies, consultants, and foundations. Current tenants at 654 Madison Avenue include Clover Group, Lakewood Advisors, and LCA Capital.

Don’t hesitate to get in touch with us if you need help in your search for an office on the Upper East Side of New York NY or elsewhere!


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